abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. MATERIALS AND METHODS:Resected lung cancer specimens were ...

journal_title：Anticancer research

authors： Shimizu K,Okita R,Saisho S,Maeda AI,Nojima Y,Nakata M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Tumor budding and a proficient mismatch repair (pMMR) status are considered adverse prognostic factors in colorectal cancer (CRC). The aim of this pilot study was to assess tumor budding in primary CRC with pMMR versus that with deficient mismatch repair (dMMR). MATERIALS AND METHODS:Tumor budding was retro...

journal_title：Anticancer research

authors： Karlberg M,Stenstedt K,Hallström M,Ragnhammar P,Lenander C,Edler D

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:Metastases involving the adrenal glands can be treated surgically or with radiation therapy. Retrospective studies indicate that radiotherapy for this indication is safe, well-tolerated and associated with symptom palliation and good local control. We conducted this analysis to report on patterns and out...

journal_title：Anticancer research

authors： Buergy D,Rabe L,Siebenlist K,Stieler F,Fleckenstein J,Giordano FA,Wenz F,Boda-Heggemann J

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Despite many years of clinical research and development, nausea and vomiting remain challenging toxicities related to chemotherapy. The aim of our study was to clarify the significance of non-pharmacological, patient-related risk factors for chemotherapy-induced nausea and vomiting. Furthermore, we aimed to ...

journal_title：Anticancer research

authors： Rittmeister H,Oskay-Özcelik G,Richter R,Sehouli J,Grabowski JP

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:There is no definite consensus regarding management of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). This study aimed to compare clinical outcomes according to initial treatment modality for treatment of naïve HCC combined with subsegmental (Vp1)/ segmental (Vp2) PVTT with live...

journal_title：Anticancer research

authors： Yu JI,Choi GS,Lim DH,Lee E,Joh JW,Kwon CHD,Kim JM,Kim S,Woo SY,Paik SW,Park HC

更新日期：2018-08-01 00:00:00

abstract：:The continuity of the subepithelial band of lamina propria-indigenous macrophages (SBLP-M) discourages commensal gut bacteria from invading the host. In this Review we analyzed the impact of a disintegrating SBLP-M in inflammatory bowel disease (IBD), which results in microbiota inflow, inadequate immune responses and...

journal_title：Anticancer research

authors： Rubio CA,Schmidt PT

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) have provided backbone structure for the chemical synthesis of potent anticancer drugs. In this study, the cytotoxicity of fifteen 2-(N-cyclicamino)chromone derivatives was investigated and subjected to quantitative structure-activity relationship (QSAR) analysis. MATE...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Sakagami H,Tomomura M,Tomomura A,Uesawa Y,Takao K,Sugita Y

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:The toxicity of the proteasome inhibitor MG132 was tested alone and combined either with the topoisomerase I inhibitor topotecan or the topoisomerase II inhibitor etoposide against a panel of 18 cell lines representing six pediatric tumor types. MATERIALS AND METHODS:MG132, topotecan, etoposide and thei...

journal_title：Anticancer research

authors： Destanovic E,Boos J,Lanvers-Kaminsky C

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Only 30-50% of patients with sentinel lymph node (SLN) metastases present with further axillary lymph node metastases. Therefore, up to 70% of patients with positive SLN are overtreated by axillary dissection (AD) and may suffer from complications such as sensory disturbances or lymphedema. According to ...

journal_title：Anticancer research

authors： Gruber I,Henzel M,Schönfisch B,Stäbler A,Taran FA,Hahn M,Röhm C,Helms G,Oberlechner E,Wiesinger B,Nikolaou K,LA Fougère C,Wallwiener D,Hartkopf A,Krawczyk N,Fehm T,Brucker S

更新日期：2018-07-01 00:00:00

abstract：: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...

journal_title：Anticancer research

authors： Baxa J,Matouskova T,Ludvik J,Sedlmair M,Flohr T,Schmidt B,Bejcek J,Pesek M,Ferda J

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MAL...

journal_title：Anticancer research

authors： Torata N,Kubo M,Miura D,Ohuchida K,Mizuuchi Y,Fujimura Y,Hayakawa E,Kai M,Oda Y,Mizumoto K,Hashizume M,Nakamura M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Perioperative intra-abdominal infection has been reported as a risk factor for metastasis. The aim of this study was to investigate the mechanism by which peritonitis induces immunosuppression in the lung, which in turn promotes lung metastasis. MATERIALS AND METHODS:C57BL/6 mice were intravenously admi...

journal_title：Anticancer research

authors： Arimoto A,Yamashita K,Hasegawa H,Sugita Y,Fukuoka E,Tanaka T,Suzuki S,Kakeji Y

更新日期：2018-07-01 00:00:00

abstract：:Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis...

journal_title：Anticancer research

authors： Bolm L,Käsmann L,Paysen A,Karapetis C,Rades D,Wellner UF,Keck T,Watson DI,Hummel R,Hussey DJ

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Hypoxia offers resistance to therapy in human solid tumors. The aim of the study was to investigate whether SN-38, the active metabolite of irinotecan, acts as a radiosensitizer through inhibition of hypoxia-inducible factor (HIF)-1α in the human colorectal cancer (CRC) cells. MATERIALS AND METHODS:HT29...

journal_title：Anticancer research

authors： Okuno T,Kawai K,Hata K,Murono K,Emoto S,Kaneko M,Sasaki K,Nishikawa T,Tanaka T,Nozawa H

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Failure of cancer chemotherapy caused by multidrug resistance (MDR) of tumor cells is mediated by ABC transporters that reduce the uptake of cytotoxic agents. Similar transporters are responsible for amyloid clearance in nerve cells in Alzheimer's disease (AD). The aim of this study was to compare the bi...

journal_title：Anticancer research

authors： Molnar J,Ocsovszki I,Pusztai R

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:MicroRNAs (miRNAs) are closely associated with a number of cellular processes, including cell development, differentiation, proliferation, carcinogenesis, and apoptosis. The aim of the present study was to elucidate the molecular mechanisms underlying the tumor suppressor activity of miRNA-203 (miR-203) ...

journal_title：Anticancer research

authors： Kim JS,Choi DW,Kim CS,Yu SK,Kim HJ,Go DS,Lee SA,Moon SM,Kim SG,Chun HS,Kim J,Kim JK,Kim DK

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:The purpose of this study was to consider appropriate application of liquid and re-biopsy through analysis of current status in practice. PATIENTS AND METHODS:We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer wh...

journal_title：Anticancer research

authors： Komiya K,Nakashima C,Nakamura T,Hirakawa H,Abe T,Ogusu S,Takahashi K,Takeda Y,Egashira Y,Kimura S,Sueoka-Aragane N

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identi...

journal_title：Anticancer research

authors： Hagi T,Nakamura T,Sugino Y,Matsubara T,Asanuma K,Sudo A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of organs at risk with prostate radiotherapy (RT) is lower in the prone position. This study is a prospective evaluation of setup accuracy, side-effects, and quality of life (QOL) during and after prone positioned RT. PATIENTS AND METHODS:Image-guided (IG) intensity-modulated (IM) RT was admini...

journal_title：Anticancer research

authors： Varga L,Kószó RL,Fodor E,Cserháti A,Varga Z,Darázs B,Kahán Z,Hideghéty K,Borzási E,Szabó D,Müllner K,Maráz A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis. PATIENTS AND METHODS:A 94-year-old fema...

journal_title：Anticancer research

authors： Pirlamarla AK,Tang J,Amin B,Kabarriti R

更新日期：2018-06-01 00:00:00

abstract：:Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

journal_title：Anticancer research

authors： Tungsukruthai S,Petpiroon N,Chanvorachote P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:In breast cancer (BC) care, radiation therapy (RT) is an efficient treatment to control localized tumor. Radiobiological research is needed to understand molecular differences that affect radiosensitivity of different tumor subtypes and the response variability. The aim of this study was to analyze gene ...

journal_title：Anticancer research

authors： Minafra L,Bravatà V,Cammarata FP,Russo G,Gilardi MC,Forte GI

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Previous studies have revealed that zinc finger and BTB domain-containing 7A (ZBTB7A), an important proto-oncogene, plays multiple roles in carcinogenesis and is up-regulated in several human malignancies. However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this...

journal_title：Anticancer research

authors： Joo JW,Kim HS,Do SI,Sung JY

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor...

journal_title：Anticancer research

authors： Ramqvist T,Ursu RG,Haeggblom L,Mirzaie L,Gahm C,Hammarstedt-Nordenvall L,Dalianis T,Näsman A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:The main objective of the present study was to evaluate the significance of apoptosis in the Fletcher's risk classification for gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS:Apoptotic cells were identified by immunostaining for single-stranded DNA (ssDNA). We assigned each GIST to one o...

journal_title：Anticancer research

authors： Mochizuki K,Kondo T,Oishi N,Tahara I,Inoue T,Kasai K,Nakazawa T,Katoh R

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Osteoscopy is a minimally-invasive endoscopic technique for inspecting lesions inside bone marrow cavities. We describe the feasibility of osteoscopic surgery of giant cell tumor of bone (GCTB) in order to preserve the proximal fibula, and thereby achieve immediate recovery and avoid complications. PATIENTS...

journal_title：Anticancer research

authors： Futani H,Kumanishi S,Minakawa GO,Yoshiya S

更新日期：2018-05-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS:Primary ...

journal_title：Anticancer research

authors： Pasqualetti F,Panichi M,Sainato A,Baldaccini D,Cocuzza P,Gonnelli A,Montrone S,Molinari A,Barbiero S,Bruschi A,Notini E,Ursino S,Mazzotti V,Morganti R,Coraggio G,Cantarella M,Erba PA,Paiar F

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an al...

journal_title：Anticancer research

authors： Machairas N,Papaconstantinou D,Stamopoulos P,Prodromidou A,Garoufalia Z,Spartalis E,Kostakis ID,Sotiropoulos GC

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

journal_title：Anticancer research

authors： Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in c...

journal_title：Anticancer research

authors： Iseki Y,Shibutani M,Maeda K,Nagahara H,Fukuoka T,Matsutani S,Hirakawa K,Ohira M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study, we showed that amentoflavone promotes sorafenib-induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether amentoflavone augments anticancer efficacy of sorafenib in HCC in vivo is unknown. The aim of the present study was to verify the anticancer effect of ...

journal_title：Anticancer research

authors： Tsai JJ,Hsu FT,Pan PJ,Chen CW,Kuo YC

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 ...

journal_title：Anticancer research

authors： Snyder R,Libby T,Raciti P,Amin B,Jacobson M,Rakheja D,Fleming K,Bartenstein M,Zhu C,Goel S,Verma AK,Shastri A

更新日期：2018-04-01 00:00:00

abstract：:Several skeletal aberrations of the skull have been described for the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Recently, periapical cemental/cemento-osseous dysplasia (COD) has been described in females affected with NF1. This reactive lesion of the hard tissues in tooth-bearing areas of the jaw h...

journal_title：Anticancer research

authors： Friedrich RE,Reul A

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:As cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being increasingly adopted as the standard treatment for peritoneal surface malignancies, familiarity with this procedure's adverse events is also growing. Herein, we describe an unreported adverse event of exocrine panc...

journal_title：Anticancer research

authors： Naffouje SA,Salti GI

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND/AIM:To identify predictors of local control and survival after whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown primary (CUP). PATIENTS AND METHODS:In 140 patients receiving WBI alone or following resection, seven factors were investigated including treatment approach, WBI-regime...

journal_title：Anticancer research

authors： Rades D,Dziggel L,Janssen S,Khoa MT,Duong VN,Khiem VH,Gebauer N,Bartscht T,Schild SE

更新日期：2018-04-01 00:00:00

abstract：:The widespread use of endoscopy and imaging in combination with the continuous update of the staging systems for neuroendocrine tumors has led to an increase in the incidence of small intestinal neuroendocrine tumors (si-NENs) globally. Despite high survival rates, severe complications may occur even in early stages d...

journal_title：Anticancer research

authors： Moris D,Ntanasis-Stathopoulos I,Tsilimigras DI,Vagios S,Karamitros A,Karaolanis G,Griniatsos J,Papalampros A,Papaconstantinou I,Glantzounis GK,Spartalis E,Blazer DG 3rd,Felekouras E

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIM:The expression of sphingosine kinase-1 (SphK1) has been reported in several cancers. However, the exact roles of SphK1 in cancer progression still remain unknown. The aim of the present study was to investigate SphK1 expression in oral squamous cell carcinoma (OSCC) and clarify the involvement of SphK1 i...

journal_title：Anticancer research

authors： Kato K,Shimasaki M,Kato T,Segami N,Ueda Y

更新日期：2018-03-01 00:00:00